Staring at a cabinet full of serums, creams and gels and trying to figure out how and when to apply them all for the best results can be overwhelming, but the easiest way to think about it, according to Dr. Francesca Fusco of, is go from lightest to heaviest. Here’s your cheat sheet: After cleansing, apply eye cream (then avoid the area—layering products can irritate the area’s delicate skin), followed by serums (you can layer a couple on top of each to target different skin concerns, but give them each a minute or so to absorb), then moisturizers or light creams, then—for an extra boost of radiance and hyration—oils (some oils feel as light as serums, but their makeup doesn’t allow moisturizers to penetrate through them to the skin). The last step in your routine depends on the time of day: In the morning, finish with sunscreen. It acts as a barrier and anything you put on top will reduce its effectiveness, so use a light hand when applying your foundation. In the evening, finish with a retinoid—the creams and serums you put on before it will help prevent redness and dryness.